Cancer proliferation by integrin stimulation from nanoparticles

Tumours are highly heterogeneous, even for the same individual, because tumours and normal cells belong to different hierarchical levels and complexities. Cancer cell growth, among other factors, depends on the dynamical interactions between the cell and its extracellular matrix (ECM). Besides random genomic mutations, signal transductions also activate cell growth via mechanical, thermodynamic, and electrical polar interactions between the microenvironment of ECM and cell stress proteins. A combination of state-of-the-art image analysis of cancer cells, phosphorylation reactions, and robust mathematical models of information and hierarchy identifies the size distribution of nanoparticles (NPs) in the cell’s ECM and the type of physical forces and interactions that stimulate integrins and activate cancer cell growth and metastasis. It is found that cancer is progressing via electrical dipole interactions between NPs in the ECM and the MIDAS or ADMIDAs binding sites of cell integrins. The integrin activation and tumour cell growth were also placed within the frame of NP’s electrical polarization using microwave fields. By applying quantum field theory, it is found that the quantum interaction between polarized NPs and microwave fields is a key player in cancer cell proliferation. The work contributes toward recognizing different cytoskeletal stressing modes in cancer cells.

Relevant publications

Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions.
V. V. Semashko, M. S. Pudovkin, A.C Cefalas, P.V. Zelenikhin , V. E. Gavriil, A. S. Nizamutdinov , Z. Kollia, A. Ferraro and E. Sarantopoulou,
Nanoscale Res. Lett. 13(1), 370 (2018).
DOI: 10.1186/s11671-018-2775-z

Dynamics and Physics of Integrin Activation in Tumor Cells by Nano-Sized Extracellular Ligands and Electromagnetic Fields.
A.C. Cefalas, V. Gavriil, A. Ferraro, Z. Kollia and E. Sarantopoulou,
“The Integrin Interactome.” Editors: Vicente-Manzanares, Miguel (Ed.), Springer Science+Business Media, LLC, part of Springer Nature, pp.199-233, (available online 2020), 2021.

Conference Presentations

Activation of cancer cell growth from a synergetic interaction between integrins and nanoparticles,
V.Gavriil*, E. Sarantopoulou, Z. Kollia, A.C. Cefalas, A. Ferraro, V.V. Semashko, M.S. Pudovkin, A.S. Nizamutdinov and P.V. Zelenikhin,
16th International Conference on Nanosciences and Nanotechnologies (NN19), Thessaloniki, Greece; July 2-5, 2019 (Oral).

Cytoskeletal stressing modes in cancer cells,
V. Gavriil, E. Sarantopoulou, Z. Kollia, M. Goulielmaki, V. Zoumpourlis and A.C. Cefalas*,
24th World Congress on Advances in Oncology & 24th International Symposium on Molecular
Medicine, Mystras, Sparta, Greece; October 10-12, 2019 (Oral).

Mechanical stimulus by rare-earth fluoride nanoparticles promotes tumour growth in vitro,
A. C. Cefalas*, M. Pudovkin, A. Ferraro, V. Gavriil, E. Sarantopoulou, P. Zelenikhin, A.
Nizamutdinov, Z. Kollia and V. V. Semashko,
III international conference on nanoparticles, nanomaterials and Applications, ISN2A 2018, Caparica, Portugal, 22-25 January 2018 (Oral).

Small size charged nanoparticles activate tumor cell growth,
V.V. Semashko, M.S. Pudovkin, P.V. Zelenikhin, V.E. Gavriil, A.S. Nizamutdinov, Z. Kollia, A. Ferraro, E. Sarantopoulou and A.C. Cefalas*,
17th Scientific conference-school, University of Saransk, Suransk, Mordovia, Russian Federation, 18-21 September 2018 (Plenary).

Non-functionalized rare–earth fluoride nanoparticles promote tumour growth in vitro,
A. Ferraro, M. Pudovkin, V. Gavriil, E. Sarantopoulou*, P. Zelenikhin, A. Nitzamudinov, Z. Kollia, V. V. Semashko, A. C. Cefalas”,
EMN meeting, FFSCI-NanoScience/EMN Croatia Meeting, Dubrovnik, Croatia; May 03-07, 2017 (Poster).

Non-functionalized fluoride-based nanoparticles increase growth of carcinogenic cells,
A. Ferraro, M. Pudovkin, V. Gavriil, E. Sarantopoulou, P. Zelenikhin, A. Nizamutdinov, V. Semashko, and A.C. Cefalas.
14th International Conference on Nanosciences and Nanotechnologies (NN17), Thessaloniki, Greece; July 4-7, 2017 (Oral).